antibody

PPARGC1A Antibody

MBS153329

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

PPARGC1A Antibody

PPARGC1A

PPARGC1A; LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1(alpha); LEM6; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Ligand effect modulator 6; PGC-1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; L-PGC-1alpha; PPARGC-1-alpha; ligand effect modulator-6; PPAR gamma coactivator variant form; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; Ligand effect modulator 6

PPARGC1A

PPARGC1A; PPARGC1A; LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1(alpha); LEM6; PGC1; PGC1A; PPARGC1; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha

PRGC1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

798

PPARGC1A antibody is human, mouse and rat reactive. At least three isoforms of PPARGC1A are known to exist; this antibody will detect all three isoforms.

PPARGC1A antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

PPARGC1A antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

PPARGC1A antibody can be used for detection of PPARGC1A by Western blot at 1 - 2 mug/ml. Antibody can also be used for Immunohistochemistry at 5 mug/mL. For Immunoflorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: PPARGC1A antibody was raised against a 17 amino acid peptide near the amino terminus of human PPARGC1A. Buffer: PPARGC1A antibody is supplied in PBS containing 0.02% sodium azide.

The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), also known as LEM-6, is a transcriptional coactivator that regulates the genes involved in energy metabolism (1). PPARGC1A interacts with PPARgamma, which permits the interaction of PPARGC1A with multiple transcription factors. PPARGC1A can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination (2). PPARGC1A may be also involved in the development of obesity (3).

7019499

NP_037393

NM_013261.3

Q9UBK2

Predicted: 88 kDa. Observed: 99 kDa

AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); ATF-2 Transcription Factor Network Pathway (138006); Activation Of PPARGC1A (PGC-1alpha) By Phosphorylation Pathway (1127496); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Adipogenesis Pathway (198832); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (477138); Circadian Clock Pathway (187173); Developmental Biology Pathway (477129)

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

PGC-1 alpha: a transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor genes. Interacts with, and regulates the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). Regulates many genes involved in energy metabolism. Provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. May be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Its transcription is repressed by ZNF746 which binds to insulin response sequences in its promoter. Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions. Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 4p15.1. Cellular Component: nucleoplasm; PML body; DNA-directed RNA polymerase II, core complex; cytosol; nucleus. Molecular Function: ligand-dependent nuclear receptor binding; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; DNA binding; androgen receptor binding; RNA binding; chromatin DNA binding; sequence-specific DNA binding; ubiquitin protein ligase binding; transcription coactivator activity; nucleotide binding; transcription factor binding. Biological Process: circadian rhythm; response to muscle activity; positive regulation of transcription, DNA-dependent; positive regulation of smooth muscle cell proliferation; thermoregulation; positive regulation of gluconeogenesis; regulation of transcription, DNA-dependent; flavone metabolic process; protein complex assembly; circadian regulation of gene expression; negative regulation of neuron apoptosis; negative regulation of glycolysis; mitochondrion organization and biogenesis; transcription initiation from RNA polymerase II promoter; protein stabilization; RNA splicing; organelle organization and biogenesis; cellular respiration; androgen metabolic process; regulation of circadian rhythm; gluconeogenesis; response to starvation; response to leucine; positive regulation of fatty acid oxidation; androgen receptor signaling pathway; digestion; brown fat cell differentiation; galactose metabolic process; cell glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of histone acetylation; positive regulation of transcription factor activity; fatty acid oxidation; response to cold; mRNA processing

0.1 mg

345 USD