MD-2 Recombinant Protein | MyBioSource MBS153316 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

MD-2 Recombinant Protein

catalog :

MBS153316

quantity :

0.05 mg

price :

250 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS153316

products type :

Recombinant Protein

products full name :

MD-2 Recombinant Protein

products short name :

MD-2

products name syn :

MD-2; MD2; MD-2; ly-96; ESOP-1; ESOP1; MD2; Lymphocyte antigen 96; Ly-96; lymphocyte antigen 96

other names :

MD-2 protein; Lymphocyte antigen 96; lymphocyte antigen 96; protein MD-2; myeloid differentiation protein-2; lymphocyte antigen 96; ESOP-1; Protein MD-2

products gene name :

LY96

other gene names :

LY96; LY96; MD2; MD-2; ly-96; ESOP-1; ESOP1; MD2; Ly-96

uniprot entry name :

LY96_HUMAN

sequence length :

160

sequence :

aa 2 - 160

purity :

~95%

form :

Liquid

storage stability :

Store in working aliquots at -70 degree C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

tested application :

ELISA (EIA), Western Blot (WB),

app notes :

This recombinant protein can be used for WB, ELISA, MS and neutralization assays.

other info1 :

Source: E Coli. Buffer: 1X PBS containing 0.1% SDS

products description :

MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

ncbi gi num :

7662504

ncbi acc num :

NP_056179

ncbi gb acc num :

NM_015364.2

uniprot acc num :

Q9Y6Y9

ncbi mol weight :

22 kDa (Calculated)

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway (187088); IKK Complex Recruitment Mediated By RIP1 Pathway (187090); Immune System Pathway (106386); Innate Immune System Pathway (106387); MyD88-independent Cascade Pathway (106401); MyD88:Mal Cascade Initiated On Plasma Membrane Pathway (106390); NF-kappa B Signaling Pathway (634527); Pathogenic Escherichia Coli Infection Pathway (83103); Pathogenic Escherichia Coli Infection Pathway (672459)

ncbi summary :

This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

uniprot summary :

LY96: a secreted protein that binds to the extracellular domains of TLR2 and TLR4. Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor complex, a multi-protein complex containing at least CD14, LY96 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 8q21.11. Cellular Component: extracellular space; plasma membrane; lipopolysaccharide receptor complex; endosome membrane. Molecular Function: protein binding; lipopolysaccharide receptor activity; coreceptor activity. Biological Process: MyD88-dependent toll-like receptor signaling pathway; I-kappaB kinase/NF-kappaB cascade; cell surface receptor linked signal transduction; MyD88-independent toll-like receptor signaling pathway; detection of lipopolysaccharide; positive regulation of lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; innate immune response; cellular defense response; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway

size1 :

0.05 mg

price1 :

250 USD

more info or order :

MyBioSource product webpage