IL-33 Recombinant Protein | MyBioSource MBS153303 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

IL-33 Recombinant Protein

catalog :

MBS153303

quantity :

0.05 mg

price :

270 USD

more info or order :

MyBioSource product webpage

image

image 1 :

SDS-PAGE analysis of recombinant IL-33 fragment on Coomassie Blue-stained 4-20% gradient gel.

product information

catalog number :

MBS153303

products type :

Recombinant Protein

products full name :

IL-33 Recombinant Protein

products short name :

[IL-33]

products name syn :

[IL-33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; NFHEV; Interleukin-33; Interleukin-1 family member 11; IL-33; interleukin 33]

other names :

[interleukin-33 isoform 1; Interleukin-33; interleukin-33; IL-33; IL-1F11; DVS27-related protein; interleukin-1 family member 11; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules; interleukin 33; Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV]

products gene name :

[IL33]

other gene names :

[IL33; IL33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV]

uniprot entry name :

IL33_HUMAN

sequence length :

270

sequence :

aa 1 - 270

purity :

~95%

form :

Liquid

storage stability :

Store in working aliquots at -70°C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. Shipping: Ships with Dry Ice.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

This recombinant protein can be used for WB, ELISA. For research use only.

image1 heading :

SDS-PAGE

other info1 :

Source: E Coli. Species: Human. Buffer: 100mM sodium phosphate, 500mM NaCl, 25 mM imidazole, 10% gycerol. Fusion Tag: Fusion Partner: C-terminal His-tag. Predicted Molecular Weight: 30kDa (Calculated)

products description :

Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1, IL-1Ra and IL-18 (1,2). Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling (1,3) and IL-1R accessory protein (IL-1RAcP) (4). Receptor binding of IL-33 activates NF-B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine (2). Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties (5).

ncbi gi num :

15559209

ncbi acc num :

NP_254274

ncbi gb acc num :

NM_033439.3

uniprot acc num :

O95760

ncbi pathways :

Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Influenza A Pathway (217173); Influenza A Pathway (217150)

ncbi summary :

IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]

uniprot summary :

IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine. Chromosomal Location of Human Ortholog: 9p24.1. Cellular Component: extracellular space; transport vesicle; chromosome; nucleus. Molecular Function: protein binding; cytokine activity. Biological Process: T-helper 2 type immune response; negative regulation of T-helper 1 type immune response; positive regulation of T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response

size1 :

0.05 mg

price1 :

270 USD

more info or order :

MyBioSource product webpage