protein

AATF Peptide

MBS152971

0.05 mg

135 USD

Blocking Peptide

AATF Peptide

AATF

DED; BFR2; CHE1; CHE-1; DED; HSPC277; Protein AATF; Apoptosis-antagonizing transcription factor; apoptosis antagonizing transcription factor

protein AATF; Protein AATF; protein AATF; rb-binding protein Che-1; apoptosis-antagonizing transcription factor; apoptosis antagonizing transcription factor; Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1

AATF

AATF; AATF; DED; BFR2; CHE1; CHE-1; CHE1; DED

AATF_HUMAN

560

Liquid

200 ug/mL

Store AATF peptide at -20 degree C, stable for one year.

Blocking (BL)

AATF peptide is used for blocking the activity of AATF antibody.

Species: Human. Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. Location: 12 amino acids near the carboxy terminus of human AATF.

7657013

NP_036270

NM_012138.3

Q9NY61

63,133 Da

Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (106443); NRAGE Signals Death Through JNK Pathway (106444); Regulation Of Retinoblastoma Protein Pathway (137916); Signal Transduction Pathway (477114); Signalling By NGF Pathway (106439); P75 NTR Receptor-mediated Signalling Pathway (106441)

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

AATF: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Belongs to the AATF family. Protein type: Nucleolus; RNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 17q12. Cellular Component: Golgi apparatus; centrosome; focal adhesion; cytoplasm; nucleolus; nucleus. Molecular Function: leucine zipper domain binding; protein binding; tau protein binding; transcription factor activity. Biological Process: nerve growth factor receptor signaling pathway; positive regulation of apoptosis; negative regulation of amyloid precursor protein biosynthetic process; regulation of mitotic cell cycle; ribosome biogenesis and assembly; positive regulation of transcription from RNA polymerase II promoter; negative regulation of superoxide release; cell adhesion; response to DNA damage stimulus; embryonic cleavage; negative regulation of apoptosis

0.05 mg

135 USD