protein

GRB10 Peptide

MBS152893

0.05 mg

135 USD

Blocking Peptide

GRB10 Peptide

GRB10

RSS; IRBP; MEG1; GRB-IR; Grb-10; GRBIR; KIAA0207; Growth factor receptor-bound protein 10; GRB10 adapter protein; growth factor receptor-bound protein 10

growth factor receptor-bound protein 10 isoform a; Growth factor receptor-bound protein 10; growth factor receptor-bound protein 10; GRB10 adapter protein; GRB10 adaptor protein; maternally expressed gene 1; insulin receptor-binding protein Grb-IR; growth factor receptor-bound protein 10; GRB10 adapter protein; Insulin receptor-binding protein Grb-IR

GRB10

GRB10; GRB10; RSS; IRBP; MEG1; GRB-IR; Grb-10; GRBIR; KIAA0207

GRB10_HUMAN

594

Liquid

200 ug/mL

Store GRB10 peptide at -20 degree C, stable for one year.

Blocking (BL)

GRB10 peptide is used for blocking the activity of GRB10 antibody.

Species: Human. Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. Location: 17 amino acids near the carboxy terminus of human GRB10.

48762679

NP_005302

NM_005311.4

Q13322

66,487 Da

EGFR1 Signaling Pathway (198782); IGF1 Pathway (137992); IRS Activation Pathway (106425); IRS-related Events Pathway (106424); Insulin Pathway (138026); Insulin Signaling Pathway (198845); Insulin Receptor Signalling Cascade Pathway (106420); Kit Receptor Signaling Pathway (198826); PDGFR-beta Signaling Pathway (138071); SHC Activation Pathway (106422)

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

GRB10: an adaptor protein that inhibits insulin-stimulated IRS-PI (3)K-Akt signaling pathway by disrupting the association of IRS with the insulin receptor. Also binds activated PDGFR and EGFR. Preferentially localizes to the mitochondria, modulating the anti-apoptotic activity of mitochondrial Raf-1. Can translocate to the plasma membrane and lamellipodia. Three alternatively spliced isoforms have been described. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 7p12.2. Cellular Component: cytoplasm; plasma membrane; cytosol. Molecular Function: protein binding; SH3/SH2 adaptor activity; insulin receptor binding. Biological Process: negative regulation of glucose import; negative regulation of Wnt receptor signaling pathway; insulin-like growth factor receptor signaling pathway; insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of phosphorylation; response to insulin stimulus; negative regulation of glycogen biosynthetic process

0.05 mg

135 USD