catalog number :
MBS152871
products type :
Blocking Peptide
products full name :
TNFRSF14 Peptide
products short name :
[TNFRSF14]
products name syn :
[TR2; ATAR; HVEA; HVEM; CD270; LIGHTR; UNQ329/PRO509; Tumor necrosis factor receptor superfamily member 14; Herpes virus entry mediator A; Herpesvirus entry mediator A; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)]
other names :
[Tumor necrosis factor receptor superfamily member 14; Tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily member 14; CD40-like protein; herpes virus entry mediator A; tumor necrosis factor receptor-like gene2; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); tumor necrosis factor receptor superfamily, member 14; Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; Tumor necrosis factor receptor-like 2; TR2; CD_antigen: CD270]
products gene name :
[TNFRSF14]
other gene names :
[TNFRSF14; TNFRSF14; TR2; ATAR; HVEA; HVEM; CD270; LIGHTR; HVEA; HVEM; Herpesvirus entry mediator A; HveA; TR2]
uniprot entry name :
TNR14_HUMAN
concentration :
200 ug/mL
storage stability :
Store TNFRSF14 peptide at -20 degree C, stable for one year.
tested application :
Blocking (BL)
app notes :
TNFRSF14 peptide is used for blocking activity of TNFRSF14 antibody.
other info1 :
Species: Human. Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
ncbi pathways :
Adaptive Immune System Pathway (366160); Costimulation By The CD28 Family Pathway (119552); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); Immune System Pathway (106386)
ncbi summary :
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
uniprot summary :
TNFRSF14: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. Protein type: Cell cycle regulation; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1p36.32. Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane. Molecular Function: viral receptor activity; protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding. Biological Process: entry of virus into host cell; defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; T cell costimulation; positive regulation of cytokine secretion during immune response; negative regulation of alpha-beta T cell proliferation; immune response; defense response to Gram-negative bacterium