catalog number :
MBS152870
products type :
Blocking Peptide
products full name :
SLC35D2 Peptide
products short name :
SLC35D2
products name syn :
hfrc; HFRC1; SQV7L; UGTrel8; HFRC; UGTREL8; Homolog of Fringe connection protein 1; solute carrier family 35, member D2
other names :
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter isoform a; UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; SQV7-like protein; fringe connection; UDP-N-acetylglucosamine transporter; solute carrier family 35, member D2; homolog of Fringe connection protein 1; UDP-galactose transporter-related protein 8; solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2; Homolog of Fringe connection protein 1; HFRC1; SQV7-like protein; SQV7L; Solute carrier family 35 member D2; UDP-galactose transporter-related protein 8; UGTrel8
products gene name :
SLC35D2
other gene names :
SLC35D2; SLC35D2; hfrc; HFRC1; SQV7L; UGTrel8; HFRC; UGTREL8; HFRC1; SQV7L; UGTrel8
uniprot entry name :
S35D2_HUMAN
concentration :
200 ug/mL
storage stability :
Store SLC35D2 peptide at -20 degree C, stable for one year.
tested application :
Blocking (BL)
app notes :
SLC35D2 peptide is used for blocking the activity of SLC35D2 antibody.
other info1 :
Species: Human. Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. Location: 14 amino acids near the carboxy terminus of human SLC35D2.
ncbi gb acc num :
NM_007001.2
ncbi mol weight :
26,702 Da
ncbi pathways :
Defective B3GAT3 Causes JDSSDHD Pathway (1127588); Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway (1127592); Defective B4GALT7 Causes EDS, Progeroid Type Pathway (1127587); Defective CHST14 Causes EDS, Musculocontractural Type Pathway (1127591); Defective CHST3 Causes SEDCJD Pathway (1127590); Defective CHST6 Causes MCDC1 Pathway (1127593); Defective CHSY1 Causes TPBS Pathway (1127589); Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway (1127594); Defective EXT2 Causes Exostoses 2 Pathway (1127595); Defective PAPSS2 Causes SEMD-PA Pathway (1127586)
ncbi summary :
Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]
uniprot summary :
SLC35D2: Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. Belongs to the TPT transporter family. SLC35D subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 9q22.32. Cellular Component: Golgi membrane; integral to membrane. Molecular Function: nucleotide-sugar transmembrane transporter activity. Biological Process: keratan sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; keratan sulfate biosynthetic process; carbohydrate transport; pathogenesis; transmembrane transport