product summary
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company name :
MyBioSource
product type :
protein
product name :
AES Peptide
catalog :
MBS152745
quantity :
0.05 mg
price :
135 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS152745
products type :
Blocking Peptide
products full name :
AES Peptide
products short name :
AES
products name syn :
GRG; ESP1; GRG5; TLE5; AES-1; AES-2; GRG; Amino-terminal enhancer of split; Gp130-associated protein GAM; Amino enhancer of split; amino-terminal enhancer of split
other names :
amino-terminal enhancer of split isoform a; Amino-terminal enhancer of split; amino-terminal enhancer of split; groucho-related protein 5; gp130-associated protein GAM; amino-terminal enhancer of split; Gp130-associated protein GAM; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG
products gene name :
AES
other gene names :
AES; AES; GRG; ESP1; GRG5; TLE5; AES-1; AES-2; Grg-5; GRG; GRG5; Amino enhancer of split
uniprot entry name :
AES_HUMAN
sequence length :
264
form :
Liquid
concentration :
200 ug/mL
storage stability :
Store AES peptide at -20 degree C, stable for one year.
tested application :
Blocking (BL)
app notes :
AES peptide is used for blocking the activity of AES antibody.
other info1 :
Species: Human. Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. Location: 16 amino acids near the amino terminus of human AES.
ncbi gi num :
39812019
ncbi acc num :
NP_945320
ncbi gb acc num :
NM_198969.1
uniprot acc num :
Q08117
ncbi mol weight :
29,091 Da
ncbi pathways :
AMER1 Mutants Destabilize The Destruction Complex Pathway (1127621); APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway (1127616); APC Truncation Mutants Have Impaired AXIN Binding Pathway (1127617); AXIN Missense Mutants Destabilize The Destruction Complex Pathway (1127620); AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway (1127618); Androgen Receptor Signaling Pathway (198806); Degradation Of Beta-catenin By The Destruction Complex Pathway (106511); Disease Pathway (530764); Presenilin Action In Notch And Wnt Signaling Pathway (137914); Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway (169352)
ncbi summary :
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
AES: Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Belongs to the WD repeat Groucho/TLE family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: nucleus. Molecular Function: protein binding; transcription corepressor activity. Biological Process: organ morphogenesis; Wnt receptor signaling pathway; transcription, DNA-dependent; regulation of growth; multicellular organismal development; cellular response to extracellular stimulus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of protein binding; negative regulation of transcription, DNA-dependent; skeletal development
size1 :
0.05 mg
price1 :
135 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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