protein

ABCA7 Peptide

MBS152658

0.05 mg

135 USD

Blocking Peptide

ABCA7 Peptide

ABCA7

ABCX; ABCA-SSN; ATP-binding cassette sub-family A member 7; ATP-binding cassette, sub-family A (ABC1), member 7

ATP-binding cassette sub-family A member 7; ATP-binding cassette sub-family A member 7; ATP-binding cassette sub-family A member 7; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette, sub-family A (ABC1), member 7; ABCA-SSN; Autoantigen SS-N; Macrophage ABC transporter

ABCA7

ABCA7; ABCA7; ABCX; ABCA-SSN

ABCA7_HUMAN

2146

Liquid

200 ug/mL

Store ABCA7 peptide at -20 degree C, stable for one year.

Blocking (BL)

ABCA7 peptide is used for blocking the activity of ABCA7 antibody.

Species: Human. Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. Location: 18 amino acid peptide near the amino terminus of human ABCA7.

150417984

NP_061985

NM_019112.3

Q8IZY2

218,497 Da

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (106573); ABCA Transporters In Lipid Homeostasis Pathway (477112); Transmembrane Transport Of Small Molecules Pathway (106572)

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]

ABCA7: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. Belongs to the ABC transporter superfamily. ABCA family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: Golgi membrane; Golgi apparatus; cell surface; cytoplasm; apical plasma membrane; integral to membrane; plasma membrane; endosome membrane; ATP-binding cassette (ABC) transporter complex; phagocytic cup. Molecular Function: apolipoprotein A-I receptor activity; phospholipid transporter activity; transporter activity; ATPase activity; ATP binding. Biological Process: phospholipid efflux; positive regulation of ATPase activity; negative regulation of amyloid precursor protein biosynthetic process; positive regulation of phagocytosis; cholesterol efflux; peptide cross-linking; phospholipid scrambling; negative regulation of ATPase activity; transmembrane transport; phagocytosis; memory

0.05 mg

135 USD