SIRP alpha Peptide | MyBioSource MBS152154 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

SIRP alpha Peptide

catalog :

MBS152154

quantity :

0.05 mg

price :

135 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS152154

products type :

Blocking Peptide

products full name :

SIRP alpha Peptide

products short name :

SIRP alpha

products name syn :

BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1; BIT; MYD1; Tyrosine-protein phosphatase non-receptor type substrate 1; Brain Ig-like molecule with tyrosine-based activation motifs; SHP substrate 1; signal-regulatory protein alpha

other names :

tyrosine-protein phosphatase non-receptor type substrate 1; Tyrosine-protein phosphatase non-receptor type substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1; myd-1 antigen; inhibitory receptor SHPS-1; macrophage fusion receptor; CD172 antigen-like family member A; tyrosine phosphatase SHP substrate 1; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; signal-regulatory protein alpha; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84; CD_antigen: CD172a

products gene name :

SIRPA

other gene names :

SIRPA; SIRPA; BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; SHP substrate 1; SHPS-1; Bit; Sirp-alpha-1; Sirp-alpha-2; Sirp-alpha-3

uniprot entry name :

SHPS1_HUMAN

sequence length :

504

form :

Liquid

concentration :

200 ug/mL

storage stability :

Store SIRP alpha peptide at -20 degree C, stable for one year.

tested application :

Blocking (BL)

app notes :

SIRP alpha peptide is used for blocking the activity of SIRP alpha antibody.

other info1 :

Species: Human. Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. Location: 17 amino acids near the carboxy terminus of human SIRP alpha.

ncbi gi num :

18426911

ncbi acc num :

NP_542970

ncbi gb acc num :

NM_080792.2

uniprot acc num :

P78324

ncbi mol weight :

54,852 Da

ncbi pathways :

BDNF Signaling Pathway (712093); Cardiac Progenitor Differentiation Pathway (712094); Cell Surface Interactions At The Vascular Wall Pathway (106062); Cell-Cell Communication Pathway (477132); Hemostasis Pathway (106028); IL-1 Signaling Pathway (198908); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096); Prolactin Signaling Pathway (672462); Signal Regulatory Protein (SIRP) Family Interactions Pathway (187209)

ncbi summary :

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

SHPS1: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Cell adhesion; Cell surface; Receptor, misc.; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 20p13. Cellular Component: membrane; integral to membrane; plasma membrane. Molecular Function: SH3 domain binding. Biological Process: blood coagulation; cell adhesion; leukocyte migration

size1 :

0.05 mg

price1 :

135 USD

more info or order :

MyBioSource product webpage