protein

IRF4 Peptide

MBS151926

0.05 mg

135 USD

Blocking Peptide

IRF4 Peptide

IRF4

MUM1; LSIRF; NF-EM5; MUM1; Interferon regulatory factor 4; Lymphocyte-specific interferon regulatory factor; IRF-4; interferon regulatory factor 4

interferon regulatory factor 4 isoform 1; Interferon regulatory factor 4; interferon regulatory factor 4; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor; interferon regulatory factor 4; Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5

IRF4

IRF4; IRF4; MUM1; LSIRF; SHEP8; NF-EM5; MUM1; IRF-4; LSIRF

IRF4_HUMAN

451

Liquid

200 ug/mL

Store IRF4 peptide at -20 degree C, stable for one year.

Blocking (BL)

IRF4 peptide is used for blocking the activity of IRF4 antibody.

Species: Human. Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. Location: 16 amino acids near the carboxy terminus of human IRF4.

167555104

NP_002451

NM_002460.3

Q15306

51,644 Da

Apoptosis Pathway (198797); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Cytokine Signaling In Immune System Pathway (366171); IL4-mediated Signaling Events Pathway (137933); Immune System Pathway (106386); Interferon Signaling Pathway (187103); Interferon Alpha/beta Signaling Pathway (187104); Interferon Gamma Signaling Pathway (187106); TCR Signaling Pathway (198862); Type II Interferon Signaling (IFNG) Pathway (198918)

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

IRF4: Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Interacts with SPIB and DEF6. Not induced by interferons. Lymphoid cells. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; Oncoprotein; DNA-binding. Chromosomal Location of Human Ortholog: 6p25-p23. Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol; nucleus. Molecular Function: protein binding; sequence-specific DNA binding; protein-lysine N-methyltransferase activity; transcription factor binding; transcription factor activity. Biological Process: transcription, DNA-dependent; T cell activation; positive regulation of interleukin-2 biosynthetic process; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; regulation of T-helper cell differentiation; myeloid dendritic cell differentiation; defense response to protozoan; peptidyl-lysine methylation; positive regulation of interleukin-10 biosynthetic process; positive regulation of interleukin-4 biosynthetic process; positive regulation of interleukin-13 biosynthetic process; negative regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA binding. Disease: Skin/hair/eye Pigmentation, Variation In, 8

0.05 mg

135 USD