antibody

CARMA1 Antibody

MBS151587

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

CARMA1 Antibody

CARMA1

CARMA1; PPBL; BENTA; BIMP3; IMD11; CARMA1; Caspase recruitment domain-containing protein 11; CARD-containing MAGUK protein 1; Carma 1; caspase recruitment domain family, member 11

Caspase recruitment domain-containing protein 11; Caspase recruitment domain-containing protein 11; caspase recruitment domain-containing protein 11; carma 1; CARD-containing MAGUK protein 1; bcl10-interacting maguk protein 3; caspase recruitment domain family, member 11; CARD-containing MAGUK protein 1; Carma 1

CARD11

CARD11; CARD11; PPBL; BENTA; BIMP3; IMD11; CARMA1; CARMA1; Carma 1

CAR11_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

1154

CARMA1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

CARMA1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

CARMA1 antibody can be used for detection of CARMA1 by Western blot at 0.5 to 2 mug/mL. A band at approximately 125 kDa can be detected. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: CARMA1 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1. Buffer: CARMA1 Antibody is supplied in PBS containing 0.02% sodium azide.

CARMA1 Antibody: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the I K complex, thereby regulating activation of the NF- B transcription factor. Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.

172046231

Q9BXL7.3

Q9BXL7

133,284 Da

Activation Of NF-kappaB In B Cells Pathway 576251!!Adaptive Immune System Pathway 366160!!B Cell Receptor Signaling Pathway 198909!!B Cell Receptor Signaling Pathway 83081!!B Cell Receptor Signaling Pathway 492!!BCR Signaling Pathway 138058!!Downstream TCR Signaling Pathway 106418!!Downstream Signaling Events Of B Cell Receptor (BCR) Pathway 576250!!FCERI Mediated NF-kB Activation Pathway 833828!!Fc Epsilon Receptor (FCERI) Signaling Pathway 833825

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD