catalog number :
MBS151578
products full name :
RCAN2 Antibody
products short name :
RCAN2
products name syn :
RCAN2; Csp2; MCIP2; ZAKI-4; Dscr1l1; Zaki4; Calcipressin-2; Calcineurin inhibitory protein ZAKI-4; regulator of calcineurin 2
other names :
Rcan2 protein; Calcipressin-2; calcipressin-2; calcineurin inhibitory protein ZAKI-4; Down syndrome critical region gene 1-like 1; down syndrome candidate region 1-like protein 1; myocyte-enriched calcineurin interactin protein 2; myocyte-enriched calcineurin-interacting protein 2; regulator of calcineurin 2; Calcineurin inhibitory protein ZAKI-4; Down syndrome candidate region 1-like protein 1; Myocyte-enriched calcineurin-interacting protein 2; MCIP2; Regulator of calcineurin 2
products gene name :
Rcan2
other gene names :
Rcan2; Rcan2; Csp2; MCIP2; ZAKI-4; Dscr1l1; Dscr1l1; Zaki4; MCIP2
uniprot entry name :
RCAN2_MOUSE
reactivity :
Human, Mouse, Rat
purity :
RCAN2 Antibody is affinity chromatography purified via peptide column.
storage stability :
RCAN2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
RCAN2 antibody can be used for detection of RCAN2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: RCAN2 antibody was raised against a 14 amino acid synthetic peptide near the center of human RCAN2. Buffer: RCAN2 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
RCAN2 Antibody: Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
ncbi mol weight :
22,025 Da
ncbi pathways :
Thyroid Hormone Signaling Pathway 946613