catalog number :
MBS151558
products full name :
ZC3HAV1 Antibody
products short name :
ZC3HAV1
products name syn :
ZC3HAV1; ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2; PRO1677; Zinc finger CCCH-type antiviral protein 1; ADP-ribosyltransferase diphtheria toxin-like 13; zinc finger CCCH-type, antiviral 1
other names :
zinc finger CCCH-type antiviral protein 1 isoform 2; Zinc finger CCCH-type antiviral protein 1; zinc finger CCCH-type antiviral protein 1; zinc finger CCCH domain-containing protein 2; ADP-ribosyltransferase diphtheria toxin-like 13; zinc finger CCCH-type, antiviral 1; ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; Zinc finger CCCH domain-containing protein 2; Zinc finger antiviral protein; ZAP
products gene name :
ZC3HAV1
other gene names :
ZC3HAV1; ZC3HAV1; ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2; ZC3HDC2; ARTD13; ZAP
uniprot entry name :
ZCCHV_HUMAN
purity :
ZC3HAV1 Antibody is affinity chromatography purified via peptide column.
storage stability :
ZC3HAV1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
app notes :
ZC3HAV1 antibody can be used for detection of ZC3HAV1 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: ZC3HAV1 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human ZC3HAV1. Buffer: ZC3HAV1 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
ZC3HAV1 Antibody: The zinc finger antiviral protein (ZC3HAV1) is a CCCH type zinc finger protein that induces an innate immunity to infections by retrovirus by preventing the accumulation of viral RNAs in the cytoplasm and recruits the RNA processing exosome to degrade target RNAs, thereby inhibiting virus replication. ZC3HAV1 is localized in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. ZAP is a direct target gene of IRF3 action in cellular antiviral responses.
ncbi gb acc num :
NM_024625.3
ncbi mol weight :
18,586 Da
ncbi summary :
This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008]