antibody

TIRAP Antibody

MBS151549

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

TIRAP Antibody

TIRAP

TIRAP; Mal; wyatt; BACTS1; MyD88-2; MAL; Adaptor protein Wyatt; TIR domain-containing adapter protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein

TIR domain containing adaptor protein TIRAP; Toll/interleukin-1 receptor domain-containing adapter protein; toll/interleukin-1 receptor domain-containing adapter protein; adapter protein wyatt; adaptor protein Wyatt; MyD88 adapter-like protein; Toll-like receptor adaptor protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Adaptor protein Wyatt; MyD88 adapter-like protein; MyD88-2

TIRAP

TIRAP; TIRAP; Mal; wyatt; BACTS1; MyD88-2; MAL; TIR domain-containing adapter protein; MyD88-2

TIRAP_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

235

TIRAP Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

TIRAP antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

TIRAP antibody can be used for detection of TIRAP by Western blot at 0.5 to 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2 mug/mL. For immunofluorescence start at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: TIRAP antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of mouse TIRAP. Buffer: TIRAP Antibody is supplied in PBS containing 0.02% sodium azide.

TIRAP Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-kappaB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.

15705407

NP_473437

P58753

27,948 Da

AGE/RAGE Pathway 698754!!Activated TLR4 Signalling Pathway 106400!!Hepatitis B Pathway 694606!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!MyD88:Mal Cascade Initiated On Plasma Membrane Pathway 106390!!NF-kappa B Signaling Pathway 634527!!Pertussis Pathway 218111!!Pertussis Pathway 218099!!Regulation Of Toll-like Receptor Signaling Pathway 920955

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD