catalog number :
MBS151547
products full name :
ZSCAN4 Antibody
products short name :
ZSCAN4
products name syn :
ZNF494; ZNF494; Zinc finger and SCAN domain-containing protein 4; Zinc finger protein 494; zinc finger and SCAN domain containing 4
other names :
zinc finger and SCAN domain-containing protein 4; Zinc finger and SCAN domain-containing protein 4; zinc finger and SCAN domain-containing protein 4; zinc finger protein 494; zinc finger and SCAN domain containing 4; Zinc finger protein 494
products gene name :
ZSCAN4
other gene names :
ZSCAN4; ZSCAN4; ZNF494; ZNF494
uniprot entry name :
ZSCA4_HUMAN
reactivity :
Human, Mouse, Rat
purity :
ZSCAN4 Antibody is affinity chromatography purified via peptide column.
storage stability :
ZSCAN4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
ZSCAN4 antibody can be used for detection of ZSCAN4 by Western blot. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: ZSCAN4 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human ZSCAN4. Buffer: ZSCAN4 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
ZSCAN4 Antibody: Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintenance and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.
ncbi acc num :
NP_689890.1
ncbi gb acc num :
NM_152677.2
ncbi mol weight :
48,957 Da
ncbi summary :
The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]