EMX2 Antibody | MyBioSource MBS151542 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

EMX2 Antibody

catalog :

MBS151542

quantity :

0.1 mg

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, cow

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of EMX2 in human lung tissue lysate with EMX2 antibody at (A) 1 and (B) 2 g/mL.

image 2 :

Immunohistochemistry of EMX2 in human lung tissue with EMX2 antibody at 2.5 g/mL.

image 3 :

Immunofluorescence of EMX2 in human lung tissue with EMX2 antibody at 20 g/mL.

product information

catalog number :

MBS151542

products type :

Antibody

products full name :

EMX2 Antibody

products short name :

[EMX2]

products name syn :

[EMX2; Homeobox protein EMX2; Empty spiracles homolog 2]

other names :

[Homeobox protein EMX2; Homeobox protein EMX2; homeobox protein EMX2; empty spiracles homolog 2; empty spiracles-like protein 2; empty spiracles homeobox 2; Empty spiracles homolog 2; Empty spiracles-like protein 2]

products gene name :

[EMX2]

other gene names :

[EMX2; EMX2]

uniprot entry name :

EMX2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human; Predicted Species reactivity based on immunogen sequence: Mouse: (100%), Bovine (100%)

sequence length :

252

specificity :

At least two isoforms of EMX2 are known to exist; this antibody will detect both isoforms. EMX2 antibody is predicted to not cross-react with EMX1

purity :

EMX2 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

EMX2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC-P), Immunofluorescence (IF)

app notes :

EMX2 antibody can be used for detection of EMX2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 ug/mL. Optimal dilutions for each application to be determined by the researcher.

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunofluorescence (IF)

other info1 :

Conjugate: Unconjugated. Immunogen: EMX2 antibody was raised against an 18 amino acid synthetic peptide near the center of human EMX2. The immunogen is located within amino acids 60-110 of EMX2. Buffer: EMX2 Antibody is supplied in PBS containing 0.02% sodium azide. Positive Control: MBS151589: Human Lung Tissue Lysate. MBS154259: Human Lung Tissue Slide.

products description :

EMX2 Antibody: EMX2, like its closely related homolog EMX1, is a homeobox transcription factor involved in specifying cell fates in the developing central nervous system and participates in the development of olfactory neurons. EMX2 is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10.

ncbi gi num :

19862512

ncbi acc num :

Q04743.2

uniprot acc num :

Q04743

ncbi mol weight :

18,518 Da

ncbi summary :

This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009]

uniprot summary :

EMX2: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. Defects in EMX2 are the cause of schizencephaly (SCHZC). Schizencephaly is an extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro- spinal fluid. Belongs to the EMX homeobox family. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 10q26.1. Cellular Component: nucleus. Molecular Function: protein binding; sequence-specific DNA binding. Biological Process: forebrain cell migration; neuron differentiation; response to drug; anterior/posterior pattern formation; dentate gyrus development; regulation of transcription, DNA-dependent; cell proliferation in forebrain; cerebral cortex regionalization. Disease: Schizencephaly

size1 :

0.1 mg

price1 :

375 USD

more info or order :

MyBioSource product webpage