antibody

Presenilin1 Antibody

MBS151535

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

Presenilin1 Antibody

Presenilin1

Presenilin1; AD3; FAD; PS1; PS-1; S182; AD3; PSNL1; Presenilin-1; Protein S182; presenilin 1

presenilin-1 isoform I-467; Presenilin-1; presenilin-1; presenilin 1; Protein S182Cleaved into the following 3 chains:Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12; PS1-CTF12

PSEN1

PSEN1; PSEN1; AD3; FAD; PS1; PS-1; S182; AD3; PS1; PSNL1; PS-1; PS1-CTF12

PSN1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

467

Presenilin1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

Presenilin1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Presenilin1 antibody can be used for detection of presenilin1 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: Presenilin1 antibody was raised against a 23 amino acid synthetic peptide from near the carboxy terminus of human presenilin1. Buffer: Presenilin1 Antibody is supplied in PBS containing 0.02% sodium azide.

Presenilin1 Antibody: Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist. This antibody has no cross-reactivity to presenilin2.

4506163

NP_000012

NM_000021.3

P49768

48,997 Da

Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Degradation Of The Extracellular Matrix Pathway 576263!!Delta-Notch Signaling Pathway 198879!!Extracellular Matrix Organization Pathway 576262!!Neurotrophin Signaling Pathway 101143!!Neurotrophin Signaling Pathway 100064!!Notch Signaling Pathway 198891!!Notch Signaling Pathway 1084758

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

0.1 mg

345 USD