antibody

TET2 Antibody

MBS151534

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

TET2 Antibody

TET2

TET2; MDS; KIAA1546; Nbla00191; Methylcytosine dioxygenase TET2; tet methylcytosine dioxygenase 2

methylcytosine dioxygenase TET2 isoform a; Methylcytosine dioxygenase TET2; methylcytosine dioxygenase TET2; tet oncogene family member 2; probable methylcytosine dioxygenase TET2; tet methylcytosine dioxygenase 2

TET2

TET2; TET2; MDS; KIAA1546; KIAA1546

TET2_HUMAN

Polyclonal

IgG

Rabbit

Human

2002

At least two isoforms of TET2 are known to exist; this antibody will detect both isoforms.

TET2 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

TET2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB)

TET2 antibody can be used for detection of TET2 by Western blot at 1 mug/mL.

Conjugate: Unconjugated. Immunogen: TET2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human TET2. Buffer: TET2 Antibody is supplied in PBS containing 0.02% sodium azide.

TET2 Antibody: TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14% of patients with JAK2V617F-positive myeloproliferative neoplasms, and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia. Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.

187761317

NP_001120680

NM_001127208.2

Q6N021

133,481 Da

Epigenetic Regulation Of Gene Expression Pathway 1127671!!Gene Expression Pathway 105937!!TET1,2,3 And TDG Demethylate DNA Pathway 1127673

The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

0.1 mg

345 USD