antibody

LAMP-1 Antibody

MBS151533

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

LAMP-1 Antibody

LAMP-1

LAMP-1; LAMPA; CD107a; LGP120; Lysosome-associated membrane glycoprotein 1; CD107 antigen-like family member A; LAMP-1; lysosomal-associated membrane protein 1

lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane glycoprotein 1; lysosome-associated membrane glycoprotein 1; LAMP-1; CD107 antigen-like family member A; lysosome-associated membrane protein 1; lysosomal-associated membrane protein 1; CD107 antigen-like family member A; CD_antigen: CD107a

LAMP1

LAMP1; LAMP1; LAMPA; CD107a; LGP120; LAMP-1; Lysosome-associated membrane protein 1

LAMP1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

417

LAMP-1 antibody is predicted to not cross-react with LAMP-2. Due to extensive post-translational modification, LAMP-1 often migrates at higher than predicted molecular weight in SDS-PAGE.

LAMP-1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

LAMP-1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

LAMP-1 antibody can be used for the detection of LAMP-1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: LAMP-1 antibody was raised against a 15 amino acid synthetic peptide from near the center of human LAMP-1. Buffer: LAMP-1 Antibody is supplied in PBS containing 0.02% sodium azide.

LAMP-1 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome. LAMP-1 shares much homology to LAMP-2 and is thought to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression. However, the loss of both proteins resulted in embryonic lethality, suggesting that each protein possesses some unique and necessary functions.

112380628

NP_005552

NM_005561.3

P11279

Predicted: 46 kDa. Observed: 100 kDa

Lysosome Pathway 99052!!Lysosome Pathway 96865!!Phagosome Pathway 153910!!Phagosome Pathway 153859!!Senescence And Autophagy Pathway 198780!!Tuberculosis Pathway 213780!!Tuberculosis Pathway 213743

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD