antibody

Ipaf Antibody

MBS151519

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

Ipaf Antibody

Ipaf

Ipaf; CLAN; IPAF; CLAN1; CLANA; CLANB; CLANC; CLAND; CARD12; CLR2.1; CLAN; UNQ6189/PRO20215; NLR family CARD domain-containing protein 4; CARD; LRR; and NACHT-containing protein; Clan protein; NLR family, CARD domain containing 4

NLR family CARD domain-containing protein 4 isoform a; NLR family CARD domain-containing protein 4; NLR family CARD domain-containing protein 4; NOD-like receptor C4; ICE-protease activating factor; CARD, LRR, and NACHT-containing protein; caspase recruitment domain family, member 12; caspase recruitment domain-containing protein 12; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4; NLR family, CARD domain containing 4; CARD, LRR, and NACHT-containing protein; Clan protein; Caspase recruitment domain-containing protein 12; Ice protease-activating factor; Ipaf

NLRC4

NLRC4; NLRC4; CLAN; IPAF; AIFEC; CLAN1; CLANA; CLANB; CLANC; CLAND; FCAS4; CARD12; CLR2.1; CARD12; CLAN; CLAN1; IPAF; Clan protein; Ipaf

NLRC4_HUMAN

Polyclonal

IgG

Rabbit

Human

1024

Ipaf Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

Ipaf antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Ipaf polyclonal antibody can be used for the detection of Ipaf by Western blot at 1 and 2 mug/mL. A 110 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: Ipaf antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human Ipaf. Buffer: Ipaf Antibody is supplied in PBS containing 0.02% sodium azide.

Ipaf Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adaptor molecules and proteases including several members of the caspase family. Another family of proteins that functions as a critical regulator of apoptosis and NF signaling pathways is the CED-4/Apaf-1 (apoptosis protein activating factor-1) protein family. Ipaf (ICE protease activating factor) is a CED-4/Apaf-1 family member that activates caspase-1/ICE and can induce apoptosis in human cells in a caspase-1 dependent manner. Ipaf and caspase-1 are thought to interact with each other through the association of the Ipaf amino-terminal CARD (caspase recruitment domain) and amino-terminal CARD of caspase-1.

40788015

NP_067032

NM_021209.4

Q9NPP4

110 kDa

Direct P53 Effectors Pathway 137939!!Immune System Pathway 106386!!Inflammasomes Pathway 366166!!Innate Immune System Pathway 106387!!Legionellosis Pathway 469200!!Legionellosis Pathway 469186!!NOD Pathway 198792!!NOD-like Receptor Signaling Pathway 122191!!NOD-like Receptor Signaling Pathway 122131!!Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways 366164

This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

0.1 mg

345 USD