antibody

PIAS1 Antibody

MBS151513

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

PIAS1 Antibody

PIAS1

PIAS1; GBP; ZMIZ3; DDXBP1; GU/RH-II; E3 SUMO-protein ligase PIAS1; Gu-binding protein; GBP; protein inhibitor of activated STAT, 1

E3 SUMO-protein ligase PIAS1; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein ligase PIAS1; gu-binding protein; AR interacting protein; DEAD/H box-binding protein 1; RNA helicase II-binding protein; zinc finger, MIZ-type containing 3; protein inhibitor of activated STAT-1; protein inhibitor of activated STAT protein 1; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; protein inhibitor of activated STAT, 1; DEAD/H box-binding protein 1; Gu-binding protein; GBP; Protein inhibitor of activated STAT protein 1; RNA helicase II-binding protein

PIAS1

PIAS1; PIAS1; GBP; ZMIZ3; DDXBP1; GU/RH-II; DDXBP1; GBP

PIAS1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

651

PIAS1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

PIAS1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

PIAS1 antibody can be used for detection of PIAS1 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: PIAS1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human PIAS1. Buffer: PIAS1 Antibody is supplied in PBS containing 0.02% sodium azide.

PIAS1 Antibody: The PIAS proteins (protein inhibitor of activated STAT) play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS1. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS1 binds specifically to STAT1, inhibiting STAT1-mediated gene activation and also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS1 is a potent co-activator for CP2c-mediated alpha-globin expression in erythroid cells.

7706637

NP_057250

NM_016166.1

O75925

36,204 Da

Androgen Receptor Signaling Pathway 198806!!Coregulation Of Androgen Receptor Activity Pathway 138085!!Cytokine Signaling In Immune System Pathway 366171!!Hedgehog Signaling Events Mediated By Gli Proteins Pathway 137912!!Hepatitis C Pathway 173973!!Hepatitis C Pathway 173907!!IFN-gamma Pathway 138040!!IL6-mediated Signaling Events Pathway 137932!!Immune System Pathway 106386!!Integrated Breast Cancer Pathway 219801

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD