catalog number :
MBS151501
products full name :
SAPAP2 Antibody
products short name :
SAPAP2
products name syn :
SAPAP2; DAP2; SAPAP2; DAP2; Disks large-associated protein 2; DAP-2; discs, large (Drosophila) homolog-associated protein 2
other names :
Disks large-associated protein 2; Disks large-associated protein 2; disks large-associated protein 2; PSD-95/SAP90-binding protein 2; discs large-associated protein 2; SAP90/PSD-95-associated protein 2; discs, large (Drosophila) homolog-associated protein 2; PSD-95/SAP90-binding protein 2; SAP90/PSD-95-associated protein 2; SAPAP2
products gene name :
DLGAP2
other gene names :
DLGAP2; DLGAP2; DAP2; SAPAP2; DAP2; DAP-2; SAPAP2
uniprot entry name :
DLGP2_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
At least three isoforms of SAPAP2 are known to exist. This SAPAP2 antibody will not cross-react with other SAPAP proteins.
purity :
SAPAP2 Antibody is affinity chromatography purified via peptide column.
storage stability :
SAPAP2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
SAPAP2 antibody can be used for detection of SAPAP2 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: SAPAP2 antibody was raised against a 16 amino acid synthetic peptide from near the center of human SAPAP2. Buffer: SAPAP2 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
SAPAP2 Antibody: SAP90/PSD-95-associated protein 2 (SAPAP2, also known as DLGAP2) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP2 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). SAPAP2 mRNA is targeted to cell bodies in a similar manner to SAPAP1 and -4, whereas SAPAP3 mRNA is detected mainly in cell bodies.
ncbi mol weight :
108,908 Da
ncbi summary :
The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2014]
uniprot summary :
SAPAP2: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Belongs to the SAPAP family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Kinase, other. Chromosomal Location of Human Ortholog: 8p23. Cellular Component: postsynaptic membrane; postsynaptic density; neurofilament; cell junction. Molecular Function: protein binding. Biological Process: nerve-nerve synaptic transmission