product summary
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company name :
MyBioSource
product type :
antibody
product name :
Bit1 Antibody
catalog :
MBS151489
quantity :
0.1 mg
price :
345 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunocytochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS151489
products type :
Antibody
products full name :
Bit1 Antibody
products short name :
Bit1
products name syn :
Bit1; BIT1; PTH2; CGI-147; BIT1; Peptidyl-tRNA hydrolase 2; mitochondrial; Bcl-2 inhibitor of transcription 1; PTH 2; peptidyl-tRNA hydrolase 2
other names :
peptidyl-tRNA hydrolase 2, mitochondrial; Peptidyl-tRNA hydrolase 2, mitochondrial; peptidyl-tRNA hydrolase 2, mitochondrial; PTH 2; bcl-2 inhibitor of transcription 1; cilia and flagella associated protein 37; peptidyl-tRNA hydrolase 2; Bcl-2 inhibitor of transcription 1
products gene name :
PTRH2
other gene names :
PTRH2; PTRH2; BIT1; PTH2; CFAP37; CGI-147; BIT1; PTH2; PTH 2
uniprot entry name :
PTH2_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
179
purity :
Bit1 Antibody is affinity chromatography purified via peptide column.
form :
Liquid
concentration :
1 mg/mL
storage stability :
Bit1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
app notes :
Bit1 antibody can be used for the detection of Bit1 by Western blot at 1 - 4 mug/mL. Antibody can also be used for immunocytochemistry starting at 2 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: Bit1 antibody was raised against a 15 amino acid synthetic peptide from near the amino-terminus of human Bit1. Buffer: Bit1 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
Bit1 Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apoptosis induced by integrin detachment. Bit1 (Bcl-2 inhibitor of transcription 1) was recently identified as being involved in this process. Bit1 is a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. Both AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. It has been suggested that Bit1-AES complexes turn off a survival-promoting gene transcription program controlled by TLE. Interestingly, apoptosis of cells transfected with Bit1 and AES could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.
ncbi gi num :
7706351
ncbi acc num :
NP_057161
ncbi gb acc num :
NM_016077.3
uniprot acc num :
Q9Y3E5
ncbi mol weight :
19,194 Da
ncbi pathways :
Apoptosis Modulation And Signaling Pathway 198822
size :
0.1 mg
price :
345 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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