antibody

IRF4 Antibody

MBS151469

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

IRF4 Antibody

IRF4

IRF4; MUM1; LSIRF; NF-EM5; MUM1; Interferon regulatory factor 4; Lymphocyte-specific interferon regulatory factor; IRF-4; interferon regulatory factor 4

interferon regulatory factor 4 isoform 1; Interferon regulatory factor 4; interferon regulatory factor 4; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor; interferon regulatory factor 4; Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5

IRF4

IRF4; IRF4; MUM1; LSIRF; SHEP8; NF-EM5; MUM1; IRF-4; LSIRF

IRF4_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

451

IRF4 antibody is predicted to not cross-react with other IRF protein family members. IRF4 often migrates at a higher than predicted molecular weight in SDS-PAGE.

IRF4 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

IRF4 antibody can be stored at 4 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

IRF4 antibody can be used for detection of IRF4 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: IRF4 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human IRF4. Buffer: IRF4 Antibody is supplied in PBS containing 0.02% sodium azide.

IRF4 Antibody: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Another member, IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF4 expression is tightly regulated in resting primary T cells and plays an essential role in the homeostasis and function of mature lymphocytes. IRF4 is induced by Toll-like receptor (TLR) activation and acts as a negative regulator of TLR signaling.

167555104

NP_002451

NM_002460.3

Q15306

51,644 Da

Apoptosis Pathway 198797!!Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993!!Cytokine Signaling In Immune System Pathway 366171!!IL4-mediated Signaling Events Pathway 137933!!Immune System Pathway 106386!!Interferon Signaling Pathway 187103!!Interferon Alpha/beta Signaling Pathway 187104!!Interferon Gamma Signaling Pathway 187106!!TCR Signaling Pathway 198862!!Type II Interferon Signaling (IFNG) Pathway 198918

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

0.1 mg

345 USD