antibody

LGI1 Antibody

MBS151464

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

LGI1 Antibody

LGI1

LGI1; EPT; ETL1; ADLTE; ADPAEF; ADPEAF; IB1099; EPITEMPIN; EPT; UNQ775/PRO1569; Leucine-rich glioma-inactivated protein 1; Epitempin-1; leucine-rich, glioma inactivated 1

LGI1; Leucine-rich glioma-inactivated protein 1; leucine-rich glioma-inactivated protein 1; epitempin-1; leucine-rich, glioma inactivated 1; Epitempin-1

LGI1

LGI1; LGI1; EPT; ETL1; ADLTE; ADPAEF; ADPEAF; IB1099; EPITEMPIN; EPT

LGI1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

557

This LGI1 antibody is predicted to be specific to LGI1 and not recognize other LGI proteins.

LGI1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

LGI1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

LGI1 antibody can be used for the detection of LGI1 by Western blot at 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: LGI1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human LGI1. Buffer: LGI1 Antibody is supplied in PBS containing 0.02% sodium azide.

LGI1 Antibody: The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Two isoforms of LGI1 are known to exist; this LGI1 antibody will recognize only the longer form.

37182888

AAQ89244

O95970

58,302 Da

This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD