antibody

BAD Antibody

MBS151457

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

BAD Antibody

BAD

BAD; BBC2; BCL2L8; BBC6; Bcl2 antagonist of cell death; Bcl-2-binding component 6; BAD; BCL2-associated agonist of cell death

Bcl2-associated agonist of cell death; Bcl2-associated agonist of cell death; bcl2-associated agonist of cell death; bcl2-L-8; BCL2-binding protein; bcl-2-like protein 8; BCL2-binding component 6; bcl-2-binding component 6; BCL-X/BCL-2 binding protein; bcl2 antagonist of cell death; BCL2-antagonist of cell death protein; bcl-XL/Bcl-2-associated death promoter; BCL2-associated agonist of cell death; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death

BAD

BAD; BAD; BBC2; BCL2L8; BBC6; BCL2L8; BAD; Bcl2-L-8

BAD_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

168

BAD Antibody is Ion exchange chromatography purified.

Liquid

1 mg/mL

BAD antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Bad antibody can be used for detection of Bad by Western blot at 0.5 to 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2 mug/mL. For immunofluorescence start at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: Bad antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human Bad. Buffer: BAD Antibody is supplied in PBS containing 0.02% sodium azide.

BAD Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain containing pro-apoptotic proteins, such as Bax, Bid, and Bik, form a growing subclass of the Bcl-2 family. Another such protein is the Bcl-2-antagonist of cell death (Bad). Bad regulates apoptosis by forming heterodimers with anti-apoptotic proteins Bcl-2 and Bcl-xL, thereby preventing them from binding with Bax. Bad activity is regulated by its phosphorylation; it is inactivated by kinases such as Akt and MAP kinase and thus promotes cell survival, whereas JNK-induced phosphorylation promotes the apoptotic role of Bad.

17371773

Q92934.3

Q92934

18,392 Da

AKT Phosphorylates Targets In The Cytosol Pathway 106475!!Activation Of BAD And Translocation To Mitochondria Pathway 105659!!Activation Of BH3-only Proteins Pathway 105658!!Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adaptive Immune System Pathway 366160!!Alpha-synuclein Signaling Pathway 137913!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD