antibody

TIP47 Antibody

MBS151454

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

TIP47 Antibody

TIP47

TIP47; PP17; TIP47; M6PRBP1; Perilipin-3; 47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; mannose-6-phosphate receptor binding protein 1

Perilipin-3; Perilipin-3; perilipin-3; placental protein 17; 47 kDa MPR-binding protein; cargo selection protein TIP47; tail-interacting protein, 47 kD; mannose-6-phosphate receptor-binding protein 1; perilipin 3; 47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; Cargo selection protein TIP47; Mannose-6-phosphate receptor-binding protein 1; Placental protein 17; PP17

M6PRBP1

PLIN3; PLIN3; PP17; TIP47; M6PRBP1; M6PRBP1; TIP47; 47 kDa MPR-binding protein; PP17

PLIN3_HUMAN

Polyclonal

IgG

Rabbit

Human, Rat

434

TIP47 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

TIP47 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

TIP47 antibody can be used for the detection of TIP47 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: TIP47 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human TIP47. Buffer: TIP47 Antibody is supplied in PBS containing 0.02% sodium azide.

TIP47 Antibody: Tail-interacting protein (TIP47) is a cytosolic protein essential for the transport of mannose-6-phosphate receptors (MPRs) from endosomes to the trans-Golgi compartments in cells. TIP47 is recruited from the cytoplasm to the late endosomal surface by the Ras-associated protein Rab9 GTPase, enabling it to bind more efficiently to MPR cytoplasmic domains. Recently, it was shown that TIP47 regulates the expression of Rab9, as expression of siRNA to TIP47 in transfected cells dramatically decreased the half-life of the Rab9 protein in addition to stabilizing the subcellular localization of Rab9. At least two isoforms of TIP47 are known to exist.

68846601

O60664.2

O60664

45,803 Da

Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]

0.1 mg

345 USD