antibody

TLR8 Antibody

MBS151442

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

TLR8 Antibody

TLR8

TLR8; CD288; Toll-like receptor 8; toll-like receptor 8

toll-like receptor 8 isoform 2; Toll-like receptor 8; toll-like receptor 8; toll-like receptor 8; CD_antigen: CD288

TLR8

TLR8; TLR8; CD288

TLR8_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

1041

TLR8 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

TLR8 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

TLR8 antibody can be used for detection of TLR8 by Western blot at 0.5 to 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 2 mug/mL. For immunofluorescence start at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: TLR8 antibody was raised against a peptide corresponding to 16 amino acids near the middle of human TLR8. Buffer: TLR8 Antibody is supplied in PBS containing 0.02% sodium azide.

TLR8 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Like TLR7, TLR8 is localized to endosomal or lysosomal compartments and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA. Human but not murine TLR8 confers responsiveness to the antiviral compound R-848.

20302168

NP_619542

NM_138636.5

Q9NR97

121,764 Da

Immune System Pathway 106386!!Innate Immune System Pathway 106387!!MyD88 Dependent Cascade Initiated On Endosome Pathway 187081!!Regulation Of Toll-like Receptor Signaling Pathway 920955!!TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway 187085!!TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation Pathway 187082!!Toll Like Receptor 7/8 (TLR7/8) Cascade Pathway 106396!!Toll Like Receptor 9 (TLR9) Cascade Pathway 106397!!Toll-Like Receptors Cascades Pathway 106388!!Toll-like Receptor Signaling Pathway 83076

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD