SCUBE1 Antibody | MyBioSource MBS151427 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SCUBE1 Antibody

catalog :

MBS151427

quantity :

0.1 mg

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of SCUBE1 in Daudi cell lysate with SCUBE1 antibody at 1 g/mL in (A) the absence and (B) the presence of blocking peptide.

image 2 :

Immunocytochemistry of SCUBE1 in Daudi cells with SCUBE1 antibody at 20 g/mL.

image 3 :

Immunofluorescence of SCUBE1 in Daudi cells with SCUBE1 antibody at 20 g/mL.

product information

catalog number :

MBS151427

products type :

Antibody

products full name :

SCUBE1 Antibody

products short name :

[SCUBE1]

products name syn :

[SCUBE1; Signal peptide; CUB and EGF-like domain-containing protein 1; signal peptide, CUB domain, EGF-like 1]

other names :

[signal peptide, CUB and EGF-like domain-containing protein 1; Signal peptide, CUB and EGF-like domain-containing protein 1; signal peptide, CUB and EGF-like domain-containing protein 1; signal peptide-CUB domain-EGF-related 1; signal peptide, CUB domain, EGF-like 1]

products gene name :

[SCUBE1]

other gene names :

[SCUBE1; SCUBE1]

uniprot entry name :

SCUB1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

988

purity :

SCUBE1 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

SCUBE1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

app notes :

SCUBE1 antibody can be used for detection of SCUBE1 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 20 mug/mL. For immunofluorescence start at 20 ug/mL. Optimal dilutions for each application to be determined by the researcher.

image1 heading :

Western Blot (WB)

image2 heading :

Immunocytochemistry (IHC)

image3 heading :

Immunofluorescence (IF)

other info1 :

Conjugate: Unconjugated. Immunogen: SCUBE1 antibody was raised against a 14 amino acid synthetic peptide near the center of human SCUBE1. Buffer: SCUBE1 Antibody is supplied in PBS containing 0.02% sodium azide.

other info2 :

Homology: Predicted species reactivity based on immunogen sequence: Mouse (93%). Positive control: Daudi Cell Lysate (Catalog Number: MBS151632)

products description :

SCUBE1 Antibody: SCUBE1 is an EGF-related protein with a CUB (C1s-like) domain that is expressed primarily in the developing gonad, nervous system, somites, surface ectoderm and limb buds. The N-terminal EGF-like repeats of SCUBE1 participate in the formation of adhesions in a Ca2+-dependent fashion. In contrast, the C-terminal cysteine-rich motifs and CUB domain can directly bind and antagonize bone morphogenic protein activity; genetic ablation of this region resulted in brain malformation in mice embryos, suggesting SCUBE1 plays a role in brain morphogenesis. SCUBE1 has also been implicated in early craniofacial development in mice.

ncbi gi num :

120587029

ncbi acc num :

NP_766638

ncbi gb acc num :

NM_173050.3

uniprot acc num :

Q8IWY4

ncbi mol weight :

107,910 Da

ncbi summary :

This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]

uniprot summary :

SCUBE1: Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. Chromosomal Location of Human Ortholog: 22q13. Cellular Component: extrinsic to plasma membrane; extracellular space; cell surface; external side of plasma membrane. Molecular Function: identical protein binding; protein heterodimerization activity; calcium ion binding. Biological Process: adult heart development; endothelial cell differentiation; blood coagulation; inflammatory response; protein homooligomerization; post-embryonic development

size1 :

0.1 mg

price1 :

375 USD

more info or order :

MyBioSource product webpage