antibody

CDCA8 Antibody

MBS151409

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

CDCA8 Antibody

CDCA8

CDCA8; BOR; DasraB; MESRGP; BOREALIN; PESCRG3; Borealin; Cell division cycle-associated protein 8; hDasra-B; cell division cycle associated 8

borealin; Borealin; borealin; Dasra B; dasra-B; hDasra-B; cell division cycle-associated protein 8; pluripotent embryonic stem cell-related gene 3 protein; cell division cycle associated 8; Cell division cycle-associated protein 8; Dasra-B; hDasra-B; Pluripotent embryonic stem cell-related gene 3 protein

CDCA8

CDCA8; CDCA8; BOR; DasraB; MESRGP; BOREALIN; PESCRG3; hDasra-B

BOREA_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

280

CDCA8 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

CDCA8 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

CDCA8 antibody can be used for detection of CDCA8 by Western blot at 1 and 2 mug/mL. Antibody can also be used for immunoflourescence starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: CDCA8 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of the human CDCA8. Buffer: CDCA8 Antibody is supplied in PBS containing 0.02% sodium azide.

CDCA8 Antibody: CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.

8922438

NP_060571

NM_018101.3

Q53HL2

31,323 Da

Aurora B Signaling Pathway 138080!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!M Phase Pathway 105812!!Mitotic Anaphase Pathway 105818!!Mitotic Metaphase And Anaphase Pathway 730317!!Mitotic Prometaphase Pathway 105815!!Resolution Of Sister Chromatid Cohesion Pathway 730315!!Separation Of Sister Chromatids Pathway 730318

This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

0.1 mg

345 USD