catalog number :
MBS151408
products full name :
SGK1 Antibody
products short name :
SGK1
products name syn :
SGK1; SGK; SGK; serum/glucocorticoid regulated kinase 1
other names :
serine/threonine-protein kinase Sgk1 isoform 1; Serine/threonine-protein kinase Sgk1; serine/threonine-protein kinase Sgk1; Sgk1 variant i3; serine/threonine protein kinase SGK; serum/glucocorticoid-regulated kinase 1; serum/glucocorticoid regulated kinase 1; Serum/glucocorticoid-regulated kinase 1
products gene name :
SGK1
other gene names :
SGK1; SGK1; SGK; SGK
uniprot entry name :
SGK1_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
SGK1 antibody is predicted to not cross-react with other SGK protein family members. At least five isoforms are known to exist
purity :
SGK1 Antibody is affinity chromatography purified via peptide column.
storage stability :
SGK1 antibody can be stored at 4 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
SGK1 antibody can be used for detection of SGK1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: SGK1 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SGK1. Buffer: SGK1 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
SGK1 Antibody: Serum and glucocorticoid-regulated protein kinase 1 (SGK1) is a member of the AGC family of serine/threonine kinases that plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. SGK1 functions as a regulator of cell survival and ion channels and transporters such as ENaC or KCNA3/Kv1.3. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.
ncbi gb acc num :
NM_005627.3
ncbi mol weight :
52,119 Da
ncbi pathways :
Aldosterone-regulated Sodium Reabsorption Pathway 130626!!Aldosterone-regulated Sodium Reabsorption Pathway 130590!!Class I PI3K Signaling Events Pathway 138022!!FSH Signaling Pathway 672455!!FoxO Family Signaling Pathway 138036!!FoxO Signaling Pathway 921162!!Glucocorticoid Receptor Regulatory Network Pathway 138014!!IL-6 Signaling Pathway 198864!!Insulin Pathway 138026!!Insulin Signaling Pathway 198845
ncbi summary :
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]