antibody

IRF7 Antibody

MBS151404

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

IRF7 Antibody

IRF7

IRF7; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H; Interferon regulatory factor 7; IRF-7; interferon regulatory factor 7

Interferon regulatory factor 7; Interferon regulatory factor 7; interferon regulatory factor 7; IRF-7; interferon regulatory factor-7H; interferon regulatory factor 7

IRF7

IRF7; IRF7; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H; IRF-7

IRF7_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

503

IRF7 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

IRF7 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

IRF7 antibody can be used for detection of IRF7 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: IRF7 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human IRF7. Buffer: IRF7 Antibody is supplied in PBS containing 0.02% sodium azide.

IRF7 Antibody: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.

116242593

Q92985.2

Q92985

55,635 Da

Activated TLR4 Signalling Pathway 106400!!Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway 187088!!Apoptosis Pathway 198797!!Cytokine Signaling In Immune System Pathway 366171!!Cytosolic DNA-sensing Pathway 125137!!Cytosolic DNA-sensing Pathway 124833!!Cytosolic Sensors Of Pathogen-associated DNA Pathway 576255!!DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway 833822!!Factors Involved In Megakaryocyte Development And Platelet Production Pathway 187196!!Hemostasis Pathway 106028

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD