antibody

APRIL Antibody

MBS151401

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

APRIL Antibody

APRIL

APRIL; APRIL; CD256; TALL2; ZTNF2; TALL-2; TRDL-1; UNQ383/PRO715; APRIL; Tumor necrosis factor ligand superfamily member 13; A proliferation-inducing ligand; tumor necrosis factor (ligand) superfamily, member 13

tumor necrosis factor ligand superfamily member 13 isoform alpha proprotein; Tumor necrosis factor ligand superfamily member 13; tumor necrosis factor ligand superfamily member 13; a proliferation-inducing ligand; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; TNF- and APOL-related leukocyte expressed ligand 2; tumor necrosis factor (ligand) superfamily, member 13; A proliferation-inducing ligand; APRIL; TNF- and APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1; TRDL-1; CD_antigen: CD256

TNFSF13

TNFSF13; TNFSF13; APRIL; CD256; TALL2; ZTNF2; TALL-2; TRDL-1; UNQ383/PRO715; APRIL; TALL2; ZTNF2; APRIL; TALL-2; TRDL-1

TNF13_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

250

APRIL Antibody is affinity chromatography purified via peptide column.

Liquid

APRIL antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

APRIL antibody can be used for detection of APRIL by Western blot at 1 - 4 mug/mL. A 27 kDa band was detected. Antibody can also be used for immunohistochemistry starting at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: APRIL antibody was raised against a synthetic peptide corresponding to amino acids within a extracellular domain of human APRIL. Buffer: APRIL Antibody is supplied in PBS containing 0.02% sodium azide.

APRIL Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1 (for TNF related death ligand 1 ) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF- B, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.

4507599

NP_003799

NM_003808.3

O75888

27 kDa

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Gene Expression Pathway 105937!!HuR Stabilizes MRNA Pathway 187216!!Intestinal Immune Network For IgA Production Pathway 128760!!Intestinal Immune Network For IgA Production Pathway 128670!!Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway 187211!!Rheumatoid Arthritis Pathway 200309!!Rheumatoid Arthritis Pathway 200269!!Spinal Cord Injury Pathway 739007

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

0.1 mg

345 USD