antibody

RHAMM Antibody

MBS151400

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

RHAMM Antibody

RHAMM

RHAMM; CD168; IHABP; RHAMM; Hyaluronan mediated motility receptor; Intracellular hyaluronic acid-binding protein; yaluronan-mediated motility receptor

hyaluronan mediated motility receptor isoform a; Hyaluronan mediated motility receptor; hyaluronan mediated motility receptor; receptor for hyaluronan-mediated motility; intracellular hyaluronic acid-binding protein; hyaluronan-mediated motility receptor (RHAMM); Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility; CD_antigen: CD168

HMMR

HMMR; HMMR; CD168; IHABP; RHAMM; IHABP; RHAMM

HMMR_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

725

RHAMM Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

RHAMM antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

RHAMM antibody can be used for detection of RHAMM by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 5 mug/mL.

Conjugate: Unconjugated. Immunogen: RHAMM antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human RHAMM. Buffer: RHAMM Antibody is supplied in PBS containing 0.02% sodium azide.

RHAMM Antibody: The hyaluronan-mediated motility receptor, also known as RHAMM, was initially identified as a soluble protein that could be released by sub-confluent migrating cells, promoting cell motility and invasion via interactions with hyaluronan (HA) and the cell surface. While RHAMM is normally poorly expressed in most normal tissues and is not required for embryonic development or normal cell homeostasis functions, its expression is increased during wound repair in response to hypoxia and fibrogenic factors. However, its overexpression is transforming in multiple types of cancers and is required for maintaining RAS transformation. RHAMM associates with BRCA1 and BARD1, attenuating the mitotic-spindle-promoting activity of RHAMM, which may contribute to tumor progression by promoting genomic instability.

217272802

NP_036617

NM_001142556.1

O75330

74,495 Da

Defective B3GAT3 Causes JDSSDHD Pathway 1127588!!Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway 1127592!!Defective B4GALT7 Causes EDS, Progeroid Type Pathway 1127587!!Defective CHST14 Causes EDS, Musculocontractural Type Pathway 1127591!!Defective CHST3 Causes SEDCJD Pathway 1127590!!Defective CHST6 Causes MCDC1 Pathway 1127593!!Defective CHSY1 Causes TPBS Pathway 1127589!!Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway 1127594!!Defective EXT2 Causes Exostoses 2 Pathway 1127595!!Defective PAPSS2 Causes SEMD-PA Pathway 1127586

The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]

0.1 mg

345 USD