antibody

VGF Antibody

MBS151354

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

VGF Antibody

VGF

VGF; Neurosecretory protein VGF; NERP-1; VGF nerve growth factor inducible

neurosecretory protein VGF; Neurosecretory protein VGF; neurosecretory protein VGF; neuro-endocrine specific protein VGF; VGF nerve growth factor inducible

VGF

VGF; VGF; NERP-1; NERP-2

VGF_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

615

VGF Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

VGF antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

VGF antibody can be used for detection of VGF by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: VGF antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human VGF. Buffer: VGF Antibody is supplied in PBS containing 0.02% sodium azide.

VGF Antibody: VGF was initially identified as a rapidly regulated gene product in nerve growth factor-treated PC12 cells. This protein is synthesized in neurons in the central and peripheral nervous system as well as in the pituitary, adrenal medulla, endocrine cells of the stomach, and pancreatic beta cells. VGF is thought to be involved in organism energy balance and regulation of homeostasis as mice lacking this gene show deficits in these areas. More recent results suggest that VGF is upregulated by brain-derived neurotrophic factor (BDNF) and can stimulate the proliferation of hippocampal progenitor cells and produce antidepressant-like behavioral effects, suggesting that this pathway may be a suitable target for therapeutic treatments.

17136078

NP_003369

NM_003378.3

O15240

Predicted: 68 kDa. Observed: 80 kDa

This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD