antibody

Acinus Antibody

MBS151348

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

Acinus Antibody

Acinus

ACN; ACINUS; fSAP152; KIAA0670; Apoptotic chromatin condensation inducer in the nucleus; Acinus; apoptotic chromatin condensation inducer 1

acinusL; Apoptotic chromatin condensation inducer in the nucleus; apoptotic chromatin condensation inducer in the nucleus; functional spliceosome-associated protein 152; apoptotic chromatin condensation inducer 1

ACIN1

ACIN1; ACIN1; ACN; ACINUS; fSAP152; ACINUS; KIAA0670; Acinus

ACINU_HUMAN

Polyclonal

IgG

Rabbit

Human

1341

Acinus Antibody is affinity chromatography purified via peptide column.

Liquid

Acinus antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB)

Acinus antibody can be used for detection of acinus by Western blot at 1 mug/mL. An approximate 220 kDa band can be detected.

Conjugate: Unconjugated. Immunogen: Acinus antibody was raised against a 16 amino acid peptide near the carboxy terminus of human Acinus. Buffer: Acinus Antibody is supplied in PBS containing 0.02% sodium azide.

Acinus Antibody: Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS'.

5931959

AAD56724

Q9UKV3

220 kDa

Apoptosis Pathway 105648!!Apoptotic Cleavage Of Cellular Proteins Pathway 105678!!Apoptotic Execution Phase Pathway 105677!!Exon Junction Complex (EJC) Pathway 470353!!Exon Junction Complex (EJC) Pathway 890638!!Programmed Cell Death Pathway 1127510!!RNA Transport Pathway 177876!!RNA Transport Pathway 175229!!Spliceosome Pathway 125136!!Spliceosome Pathway 124832

Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

0.1 mg

345 USD