antibody

SAPAP1 Antibody

MBS151337

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

SAPAP1 Antibody

SAPAP1

SAPAP1; CNF; NPHN; nephrin; Nephrin; Renal glomerulus-specific cell adhesion receptor; nephrosis 1, congenital, Finnish type (nephrin

nephrin; Nephrin; nephrin; renal glomerulus-specific cell adhesion receptor; nephrosis 1, congenital, Finnish type (nephrin); Renal glomerulus-specific cell adhesion receptor

NPHS1

NPHS1; NPHS1; CNF; NPHN; nephrin; NPHN

NPHN_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

1241

At least three isoforms of SAPAP1 are known to exist. This SAPAP1 antibody will not cross-react with other SAPAP proteins.

SAPAP1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

SAPAP1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

SAPAP1 antibody can be used for detection of SAPAP1 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: SAPAP1 antibody was raised against a 18 amino acid synthetic peptide from near the center of human SAPAP1. Buffer: SAPAP1 Antibody is supplied in PBS containing 0.02% sodium azide.

SAPAP1 Antibody: SAP90/PSD-95-associated protein 1 (SAPAP1, also known as DLGAP1 or GKAP) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP1 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). SAPAP1 mRNA is targeted to cell bodies in a similar manner to SAPAP2 and -4, whereas SAPAP3 mRNA is detected mainly in cell bodies. SAPAP1 protein however, is targeted to the synapse and is not reliant on the synaptic localization of PSD-95 or the synaptic scaffolding molecule (S-SCAM).

4758822

NP_004737

NM_004646.3

O60500

130,546 Da

Cell-Cell Communication Pathway 477132!!Nephrin Interactions Pathway 187228!!Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway 138072

This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009]

0.1 mg

345 USD