antibody

STAT1 alpha Antibody

MBS151336

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunocytochemistry, immunoprecipitation, enzyme immunoassay

Antibody

STAT1 alpha Antibody

STAT1 alpha

STAT1 alpha; CANDF7; ISGF-3; STAT91; signal transducer and activator of transcription 1, 91kDa

signal transducer and activator of transcription 1-alpha/beta isoform alpha; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1-alpha/beta; transcription factor ISGF-3 components p91/p84; signal transducer and activator of transcription-1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; Transcription factor ISGF-3 components p91/p84

STAT1

STAT1; STAT1; CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91

STAT1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

750

No reaction to the 84 kDa STAT1a.

STAT1 alpha Antibody is Antibody is DEAE purified.

Liquid

STAT1 alpha antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP)

STAT1 alpha antibody can be used for Western blot at 1:1000 to 1:2000 and for immunoprecipitation at 2 to 4 mug per sample. A 91 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: STAT1 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human STAT1 alpha. The sequences differ from the murine corresponding sequences by four amino acids. Buffer: STAT1 alpha Antibody is supplied in PBS containing 0.02% sodium azide.

STAT1 alpha Antibody: STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5a, and Stat5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN- , IFN- , IFN- and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). STAT1 has two forms, the 91 kDa STAT1 and the 84 kDa STAT1 which are encoded by the same gene with splicing variant.

6274552

NP_009330

NM_007315.3

P42224

91 kDa

AGE/RAGE Pathway 698754!!Adipogenesis Pathway 198832!!Antiviral Mechanism By IFN-stimulated Genes Pathway 530760!!B Cell Receptor Signaling Pathway 198909!!BDNF Signaling Pathway 712093!!CXCR4-mediated Signaling Events Pathway 137910!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Cytokine Signaling In Immune System Pathway 366171!!Disease Pathway 530764

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD