antibody

IRAK-4 Antibody

MBS151320

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

IRAK-4 Antibody

IRAK-4

IRAK-4; IPD1; REN64; IRAK-4; NY-REN-64; Interleukin-1 receptor-associated kinase 4; Renal carcinoma antigen NY-REN-64; interleukin-1 receptor-associated kinase 4

interleukin-1 receptor associated kinase 4; Interleukin-1 receptor-associated kinase 4; interleukin-1 receptor-associated kinase 4; renal carcinoma antigen NY-REN-64; interleukin-1 receptor-associated kinase 4; Renal carcinoma antigen NY-REN-64

IRAK4

IRAK4; IRAK4; IPD1; REN64; IRAK-4; NY-REN-64; IRAK-4

IRAK4_HUMAN

Polyclonal

IgG

Rabbit

Human

460

IRAK-4 antibody is predicted to not cross-react with other members of the IRAK protein family.

IRAK-4 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

IRAK-4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

IRAK-4 antibody can be used for the detection of IRAK-4 by Western blot at 1 to 4 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: IRAK-4 antibody was raised against a synthetic peptide corresponding to 13 amino acids near the carboxy terminus of human IRAK-4. Buffer: IRAK-4 Antibody is supplied in PBS containing 0.02% sodium azide.

IRAK-4 Antibody: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF- B and MAP kinase (MAPK) by IL-1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4. Overexpression of IRAK-4 activates NF- B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.

20219010

AAM15772

Q9NWZ3

Predicted: 51 kDa. Observed: 51 kDa

AGE/RAGE Pathway 698754!!Activated TLR4 Signalling Pathway 106400!!Apoptosis Pathway 83060!!Apoptosis Pathway 470!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Cytokine Signaling In Immune System Pathway 366171!!IL-1 Signaling Pathway 198908!!IL1-mediated Signaling Events Pathway 137944!!Immune System Pathway 106386

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

0.1 mg

345 USD