LRRFIP1 Antibody | MyBioSource MBS151272 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LRRFIP1 Antibody

catalog :

MBS151272

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS151272

products type :

Antibody

products full name :

LRRFIP1 Antibody

products short name :

LRRFIP1

products name syn :

LRRFIP1; GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1; GCF2; Leucine-rich repeat flightless-interacting protein 1; GC-binding factor 2; LRR FLII-interacting protein 1; leucine rich repeat (in FLII) interacting protein 1

other names :

leucine-rich repeat flightless-interacting protein 1 isoform 3; Leucine-rich repeat flightless-interacting protein 1; leucine-rich repeat flightless-interacting protein 1; GC-binding factor 2; NEDD8-conjugating enzyme; TAR RNA-interacting protein; LRR FLII-interacting protein 1; leucine rich repeat (in FLII) interacting protein 1; GC-binding factor 2; TAR RNA-interacting protein

products gene name :

LRRFIP1

other gene names :

LRRFIP1; LRRFIP1; GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1; GCF2; TRIP; LRR FLII-interacting protein 1

uniprot entry name :

LRRF1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

808

specificity :

LRRFIP1 antibody is predicted to not cross-react with other LRRFIP family members. Three isoforms of LRRFIP1 are known to exist; this antibody will only recognize the two longer isoforms.

purity :

LRRFIP1 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

LRRFIP1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

LRRFIP1 antibody can be used for detection of LRRFIP1 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: LRRFIP1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human LRRFIP1. Buffer: LRRFIP1 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

LRRFIP1 Antibody: LRRFIP1, also known as GC-binding factor 2 (GCF2), is a 738 amino acid transcriptional repressor that mainly plays a cytoskeletal role. It is primarily localized in the cytoplasm and preferentially binds to GC-rich dsDNA, but will also bind directly to dsRNA as well. The RNA binding domain encompasses a lysine-rich motif. LRRFIP1 interacts with the mammalian Flightless I (Fli-I) and is a key component in the cytoskeletal regulation of platelet function. LRRFIP1 and the related protein LRRFIP2 may modulate canonical WNT signaling and mediate the IRF3-induced production of type I interferon via a beta-catenin-dependent pathway.

ncbi gi num :

212276096

ncbi acc num :

NP_001131022

ncbi gb acc num :

NM_001137552.1

uniprot acc num :

Q32MZ4

ncbi mol weight :

73,060 Da

ncbi pathways :

Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); Disease Pathway (530764); Immune System Pathway (106386); Innate Immune System Pathway (106387); LRR FLII-interacting Protein 1 (LRRFIP1) Activates Type I IFN Production Pathway (833821); Signaling By FGFR In Disease Pathway (645274); Signaling By FGFR Mutants Pathway (645275); Signaling By FGFR1 Fusion Mutants Pathway (645278); Signaling By FGFR1 Mutants Pathway (645276)

uniprot summary :

LRRFIP1: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5 -AGCCCCCGGCG-3 ) and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Belongs to the LRRFIP family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 2q37.3. Cellular Component: cytoskeleton; cytoplasm; plasma membrane; cytosol; nucleus. Molecular Function: protein binding; protein homodimerization activity; DNA binding; double-stranded RNA binding. Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of interferon type I production; innate immune response; negative regulation of transcription, DNA-dependent

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage