antibody

MYD88 Antibody

MBS151266

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, enzyme immunoassay

Antibody

MYD88 Antibody

MYD88

MYD88; MYD88D; myeloid differentiation primary response gene (88)

Human myleoid differentiation primary response protein MyD88 mRNA, complete cds; myeloid differentiation primary response protein MyD88; myeloid differentiation primary response gene (88); myeloid differentiation primary response 88

MYD88

MYD88; MYD88D

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

2682

MYD88 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

MYD88 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB)

MYD88 antibody can be used for detection of MyD88 by Western blot 0.5 mug/mL. For immunohistochemistry use a concentration of 4 mug/mL. For immunofluorescence and immunocytochemistry use a concentration of 5 mug/mL.

Conjugate: Unconjugated. Immunogen: MD88 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MD88. Buffer: MYD88 Antibody is supplied in PBS containing 0.02% sodium azide.

MYD88 Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF- B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

1763090

AAB49967.1

U70451

Aprox: 35 kDa

AGE/RAGE Pathway 698754!!Activated TLR4 Signalling Pathway 106400!!African Trypanosomiasis Pathway 194384!!African Trypanosomiasis Pathway 194323!!Apoptosis Pathway 83060!!Apoptosis Pathway 470!!Apoptosis Modulation And Signaling Pathway 198822!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Cytokine Signaling In Immune System Pathway 366171

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

0.1 mg

345 USD