AP2M1 Antibody | MyBioSource MBS151264 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

AP2M1 Antibody

catalog :

MBS151264

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

chicken

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS151264

products type :

Antibody

products full name :

AP2M1 Antibody

products short name :

AP2M1

products name syn :

AP2M1; mu2; AP50; CLAPM1; KIAA0109; AP-2 complex subunit mu; AP-2 mu chain; adaptor-related protein complex 2, mu 1 subunit

other names :

AP-2 complex subunit mu isoform a; AP-2 complex subunit mu; AP-2 complex subunit mu; adaptin-mu2; AP-2 mu chain; AP-2 mu 2 chain; HA2 50 kDA subunit; clathrin coat adaptor protein AP50; clathrin coat assembly protein AP50; clathrin coat-associated protein AP50; adaptor protein complex AP-2 subunit mu; clathrin adaptor complex AP2, mu subunit; plasma membrane adaptor AP-2 50kDA protein; plasma membrane adaptor AP-2 50 kDa protein; adapter-related protein complex 2 mu subunit; adapter-related protein complex 2 subunit mu; adaptor-related protein complex 2 subunit mu; clathrin assembly protein complex 2 medium chain; clathrin assembly protein complex 2 mu medium chain; clathrin-associated/assembly/adaptor protein, medium 1; adaptor-related protein complex 2, mu 1 subunit; AP-2 mu chain; Adaptin-mu2; Adaptor protein complex AP-2 subunit mu; Adaptor-related protein complex 2 subunit mu; Clathrin assembly protein complex 2 mu medium chain; Clathrin coat assembly protein AP50; Clathrin coat-associated protein AP50; HA2 50 kDa subunit; Plasma membrane adaptor AP-2 50 kDa protein

products gene name :

AP2M1

other gene names :

AP2M1; AP2M1; mu2; AP50; CLAPM1; CLAPM1; KIAA0109

uniprot entry name :

AP2M1_HUMAN

clonality :

Polyclonal

isotype :

IgY

host :

Chicken

reactivity :

Human, Mouse, Rat

sequence length :

435

purity :

AP2M1 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

AP2M1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

AP2M1 antibody can be used for detection of AP2M1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: AP2M1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human AP2M1. Buffer: AP2M1 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

AP2M1 Antibody: The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.

ncbi gi num :

14917109

ncbi acc num :

NP_004059

ncbi gb acc num :

NM_004068.3

uniprot acc num :

Q96CW1

ncbi mol weight :

49,389 Da

ncbi pathways :

Adaptive Immune System Pathway 366160!!Arf1 Pathway 137927!!Axon Guidance Pathway 105688!!Developmental Biology Pathway 477129!!Disease Pathway 530764!!EGFR Downregulation Pathway 106342!!EPH-Ephrin Signaling Pathway 1127691!!EPH-ephrin Mediated Repulsion Of Cells Pathway 1127695!!Endocrine And Other Factor-regulated Calcium Reabsorption Pathway 213307!!Endocrine And Other Factor-regulated Calcium Reabsorption Pathway 213276

ncbi summary :

This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

size :

0.1 mg

price :

345 USD

more info or order :

MyBioSource product webpage