antibody

NALP12 Antibody

MBS151244

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

NALP12 Antibody

NALP12

NALP12; RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3; RNO; NACHT; LRR and PYD domains-containing protein 12; Monarch-1; NLR family, pyrin domain containing 12

NACHT, LRR and PYD domains-containing protein 12 isoform 2; NACHT, LRR and PYD domains-containing protein 12; NACHT, LRR and PYD domains-containing protein 12; monarch 1; regulated by nitric oxide; PYRIN-containing APAF1-like protein 7; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; NLR family, pyrin domain containing 12; Monarch-1; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide

NLRP12

NLRP12; NLRP12; RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3; NALP12; PYPAF7; RNO

NAL12_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

1061

NALP12 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

NALP12 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

NALP12 antibody can be used for detection of NALP12 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: NALP12 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP12. Buffer: NALP12 Antibody is supplied in PBS containing 0.02% sodium azide.

NALP12 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF- B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.

21955154

NP_653288

NM_144687.3

P59046

120,329 Da

NOD Pathway 198792

This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

0.1 mg

345 USD