antibody

RICK Antibody

MBS151211

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

RICK Antibody

RICK

RICK; CCK; RICK; RIP2; CARD3; GIG30; CARDIAK; UNQ277/PRO314/PRO34092; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; receptor-interacting serine-threonine kinase 2

Receptor-interacting serine/threonine-protein kinase 2; Receptor-interacting serine/threonine-protein kinase 2; receptor-interacting serine/threonine-protein kinase 2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor-interacting protein 2; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; receptor-interacting serine-threonine kinase 2; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; RIP-2; Tyrosine-protein kinase RIPK2 (EC:2.7.10.2)

RIPK2

RIPK2; RIPK2; CCK; RICK; RIP2; CARD3; GIG30; CARDIAK; CARDIAK; RICK; RIP2; CARD-containing IL-1 beta ICE-kinase; RIP-2

RIPK2_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

540

RICK Antibody is affinity chromatography purified via peptide column.

Liquid

RICK antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

RICK antibody can be used for detection of RICK by Western blot at 1 mug/mL. An approximately 60 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: RICK antibody was raised against a peptide corresponding to amino acids near the amino terminus of human RICK. Buffer: RICK Antibody is supplied in PBS containing 0.02% sodium azide.

RICK Antibody: Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively. RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF- B and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1 . The messenger RNA of RICK is expressed in multiple human tissues.

20455217

O43353.2

O43353

60 kDa

Activated TLR4 Signalling Pathway 106400!!Adaptive Immune System Pathway 366160!!Canonical NF-kappaB Pathway 138030!!Cytokine Signaling In Immune System Pathway 366171!!Downstream TCR Signaling Pathway 106418!!FAS Pathway And Stress Induction Of HSP Regulation 198894!!IL12-mediated Signaling Events Pathway 137922!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!Interleukin-1 Signaling Pathway 160141

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD