catalog number :
MBS151193
products full name :
AID Antibody
products short name :
AID
products name syn :
AID; AID; ARP2; CDA2; HIGM2; HEL-S-284; AID; Single-stranded DNA cytosine deaminase; Activation-induced cytidine deaminase; activation-induced cytidine deaminase
other names :
AID, partial; Single-stranded DNA cytosine deaminase; single-stranded DNA cytosine deaminase; cytidine aminohydrolase; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; activation-induced cytidine deaminase; Activation-induced cytidine deaminase; Cytidine aminohydrolase
products gene name :
AICDA
other gene names :
AICDA; AICDA; AID; ARP2; CDA2; HIGM2; HEL-S-284; AID
uniprot entry name :
AICDA_HUMAN
reactivity :
Human, Mouse
purity :
AID Antibody is affinity chromatography purified via peptide column.
storage stability :
AID antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
app notes :
AID antibody can be used for detection of AID by Western blot at 2 mug/mL. Anti-AID is human and mouse reactive. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: AID antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human AID. Buffer: AID Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
AID Antibody: Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines. It is necessary for somatic hypermutation and class switch recombination in B cells, but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms. Although it is structurally and functionally similar to the APOBEC proteins, it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G.
ncbi mol weight :
22,614 Da
ncbi pathways :
IL4-mediated Signaling Events Pathway 137933!!Intestinal Immune Network For IgA Production Pathway 128760!!Intestinal Immune Network For IgA Production Pathway 128670!!Primary Immunodeficiency Pathway 83125!!Primary Immunodeficiency Pathway 537
ncbi summary :
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]