antibody

PDL-2 Antibody

MBS151188

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

PDL-2 Antibody

PDL-2

PDL-2; B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2; B7DC; Programmed cell death 1 ligand 2; Butyrophilin B7-DC; PD-1 ligand 2; programmed cell death 1 ligand 2

programmed cell death 1 ligand 2; Programmed cell death 1 ligand 2; programmed cell death 1 ligand 2; B7-DC; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; programmed death ligand 2; B7 dendritic cell molecule; programmed cell death 1 ligand 2; Butyrophilin B7-DC; B7-DC; CD_antigen: CD273

PDCD1LG2

PDCD1LG2; PDCD1LG2; B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2; B7DC; CD273; PDCD1L2; PDL2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; B7-DC

PD1L2_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

273

PDL-2 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

PDL-2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

PDL-2 antibody can be used for detection of PDL-2 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: PDL-2 antibody was raised against a 16 amino acid synthetic peptide from near the center of human PDL-2. Buffer: PDL-2 Antibody is supplied in PBS containing 0.02% sodium azide.

PDL-2 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PDL-2 can act to stimulate an immunogenic response through and alternative receptor from PD-1.

190014605

NP_079515

NM_025239.3

Q9BQ51

Predicted: 30 kDa. Observed: 32 kDa

Adaptive Immune System Pathway (366160); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (119552); Immune System Pathway (106386); PD-1 Signaling Pathway (119557)

PDCD1LG2: Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 9p24.2. Cellular Component: plasma membrane; integral to membrane; endomembrane system. Biological Process: negative regulation of interleukin-10 production; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; T cell costimulation; immune response; positive regulation of T cell proliferation

0.1 mg

345 USD