antibody

BAFF Receptor Antibody

MBS151185

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

BAFF Receptor Antibody

BAFF Receptor

BAFF Receptor; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin; BAFFR; BR3; Tumor necrosis factor receptor superfamily member 13C; B-cell-activating factor receptor; tumor necrosis factor receptor superfamily, member 13C

BAFF receptor; Tumor necrosis factor receptor superfamily member 13C; tumor necrosis factor receptor superfamily member 13C; BAFF receptor; BLyS receptor 3; B cell-activating factor receptor; B-cell-activating factor receptor; tumor necrosis factor receptor superfamily, member 13C; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD_antigen: CD268

TNFRSF13C

TNFRSF13C; TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin; BAFFR; BR3; BAFF-R

TR13C_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

184

BAFF Receptor Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

BAFF Receptor antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

BAFF Receptor antibody can be used for detection of BAFF Rexeptor by Western blot at 5 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.

Conjugate: Unconjugated. Immunogen: BAFF Receptor antibody was raised against a synthetic peptide corresponding to 15 amino acids near the carboxy terminus of human BAFF Receptor The peptide sequence is identical between human and mouse origin. Buffer: BAFF Receptor Antibody is supplied in PBS containing 0.02% sodium azide.

BAFF Receptor Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF- B and c-jun N-terminal kinase.

15208475

AAK91826

Q96RJ3

20 kDa

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); NF-kappa B Signaling Pathway (634527); Primary Immunodeficiency Pathway (83125); Primary Immunodeficiency Pathway (537)

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

BAFF-R: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4); also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell cycle regulation; Receptor, misc.; Membrane protein, integral; Cell surface. Chromosomal Location of Human Ortholog: 22q13.1-q13.31. Cellular Component: integral to membrane; external side of plasma membrane. Biological Process: B cell costimulation; B cell homeostasis; T cell costimulation; positive regulation of germinal center formation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process. Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 4

0.1 mg

345 USD