antibody

DISC1 Antibody

MBS151155

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

DISC1 Antibody

DISC1

DISC1; SCZD9; C1orf136; KIAA0457; Disrupted in schizophrenia 1 protein; disrupted in schizophrenia 1

disrupted in schizophrenia 1 protein isoform L; Disrupted in schizophrenia 1 protein; disrupted in schizophrenia 1 protein; disrupted in schizophrenia 1

DISC1

DISC1; DISC1; SCZD9; C1orf136; KIAA0457

DISC1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

854

DISC1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

DISC1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

DISC1 antibody can be used for detection of DISC1 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: DISC1 antibody was raised against a 18 amino acid synthetic peptide from near the center of human DISC1. Buffer: DISC1 Antibody is supplied in PBS containing 0.02% sodium azide.

DISC1 Antibody: Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.

61742823

NP_061132

NM_018662.2

Q9NRI5

22,198 Da

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD