antibody

BCMA Antibody

MBS151091

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

BCMA Antibody

BCMA

BCMA; BCM; BCMA; CD269; TNFRSF13A; BCM; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; tumor necrosis factor receptor superfamily, member 17

tumor necrosis factor receptor superfamily member 17; Tumor necrosis factor receptor superfamily member 17; tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein; tumor necrosis factor receptor superfamily, member 17; B-cell maturation protein; CD_antigen: CD269

TNFRSF17

TNFRSF17; TNFRSF17; BCM; BCMA; CD269; TNFRSF13A; BCM; BCMA

TNR17_HUMAN

Polyclonal

IgG

Rabbit

Human

184

BCMA Antibody is affinity chromatography purified via peptide column.

Liquid

BCMA antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

BCMA antibody can be used for detection of BCMA by Western blot at 5 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: BCMA antibody was raised against a synthetic peptide mapping at the carboxy terminus of human BCMA. Buffer: BCMA Antibody is supplied in PBS containing 0.02% sodium azide.

BCMA Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF- B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

23238192

NP_001183

NM_001192.2

Q02223

14,843 Da

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670)

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2. Protein type: Oncoprotein; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 16p13.1. Cellular Component: integral to membrane; plasma membrane; endomembrane system. Molecular Function: receptor activity. Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction

0.1 mg

345 USD